| Goals | Player | Country | Date | Match |
| 5 | Lionel Messi |  ARG | March 7 2012 | Bayer Leverkusen - Barcelona |
| 4 | Bafetimbi Gomis |  FRA | December 7 2011 | Dinamo Zagreb - Lyon |
| 4 | Lionel Messi | ARG | April 6 2010 | Barcelona - Arsenal |
| 4 | A. Shevchenko |  UKR | November 23 2005 | Fenerbahce - AC Milan |
| 4 | R. van Nistelrooy |  NED | November 3 2004 | Man. United - Sparta Praha |
| 4 | Dado Prso |  CRO | November 5 2003 | Monaco - Deportivo la Coruna |
| 4 | Simone Inzaghi |  ITA | March 14 2000 | Lazio - Marseille |
| 4 | Marco van Basten | NED | November 25 1992 | AC Milan - IFK Goteborg |
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